Search results for " HIRSUTISM"

showing 7 items of 7 documents

Lower insulin sensitivity differentiates hirsute from non-hirsute Sicilian women with polycystic ovary syndrome

2006

Objective: It is well known that hyperandrogenism and insulin-resistance with or without compensatory hyperinsulinism are closely associated, but the Rotterdam Consensus has concluded that principally obese women with polycystic ovary syndrome (PCOS) should be evaluated for the metabolic syndrome. Our aim was to study insulin sensitivity in PCOS women with hirsutism regardless of obesity. Methods: Clinical characteristics, sex hormones and fasting- and after OGTT-glycemia and insulinemia, homeostatic model of insulin resistance (HOMA IR), and Matsuda index of insulin sensitivity were analyzed in 130 women with PCOS. Hirsutism has been evaluated through the Ferriman–Gallwey (FG) map scoring …

Adultmedicine.medical_specialtyHirsutismAdolescentEndocrinology Diabetes and Metabolismmedicine.medical_treatmentSettore MED/13 - EndocrinologiaDiagnosis DifferentialEndocrinologyInsulin resistanceInternal medicineHyperinsulinismmedicineHumansTestosteroneObesitySicilyhirsutismMetabolic Syndromebusiness.industryDehydroepiandrosterone SulfateInsulinHyperandrogenismAndrostenedioneGeneral Medicinemedicine.diseasePolycystic ovaryEndocrinologyPCOS INSULIN RESISTANCE HIRSUTISMFemaleMetabolic syndromeInsulin ResistancebusinessHyperandrogenismHyperinsulinismBody mass indexPolycystic Ovary Syndrome
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The diagnosis of polycystic ovary syndrome in adolescents

2010

In women, the definition of polycystic ovary syndrome (PCOS) has become broad and includes several possible phenotypes. Because several features of PCOS may be in evolution in adolescents, we suggest that only firm criteria should be used to make a diagnosis of PCOS during adolescence. Hyperandrogenism, oligomenorrhea, and ovarian morphology change during adolescence and are discussed individually. Adolescents with incomplete criteria for a firm diagnosis of PCOS should be followed up carefully and may be diagnosed at a later time.

Hirsutismmedicine.medical_specialtyAdolescentendocrine system diseasesMEDLINESettore MED/13 - EndocrinologiamedicineHumansCystAmenorrheaUltrasonographyMenarcheGynecologybusiness.industryOvaryPubertyHyperandrogenismnutritional and metabolic diseasesObstetrics and Gynecologymedicine.diseasePolycystic ovaryfemale genital diseases and pregnancy complicationsOligomenorrheaOvarian morphologyMenarcheFemaleUltrasonographyHyperandrogenismbusinessPOLYCYSTIC OVARY SYNDROME ADOLESCENCE MENSTRUAL IRREGULARITIES HIRSUTISMAnovulationPolycystic Ovary Syndrome
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Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

2011

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with a high prevalence. The etiology of this heterogeneous condition remains obscure, and its phenotype expression varies. Two widely cited previous ESHRE/ASRMsponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008), respectively. The present third PCOS consensus report summarizes current knowledge and identifies knowledge gaps regarding various women's health aspects of PCOS. Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, e…

Infertilitymedicine.medical_specialtyConsensusMEDLINEmetabolic syndromeSettore MED/13 - EndocrinologiaPolycystic Ovary Syndrome Adolescence Metabolism Cardiovascular riskMetabolic DiseasesQuality of lifeSDG 3 - Good Health and Well-beingPregnancyRisk Factorscardiovascular diseaseNeoplasmsinsulin resistancemedicineHumanscancerPolycystic ovary syndromehirsutismhirsutismGynecologybiologypregnancy complicationsbusiness.industryPolycystic ovary syndrome (PCOS)cancer; cardiovascular disease; contraception; hirsutism; insulin resistance; metabolic syndrome; Polycystic ovary syndrome; pregnancy complications; quality of life; type 2 diabetesObstetrics and GynecologyAnti-Müllerian hormonemedicine.diseasePolycystic ovarycontraceptionquality of lifeReproductive MedicineCardiovascular DiseasesFamily medicinebiology.proteinEtiologyFemaletype 2 diabetesbusinessInfertility Female
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The spectrum of androgen excess disorders.

2006

A better understanding of the different phenotypes and of their endocrine and metabolic characteristics permits investigators to distinguish three main androgen excess disorders: classic polycystic ovary syndrome (PCOS), mild ovulatory PCOS, and idiopathic hyperandrogenism. These androgenic phenotypes differ more for the severity of the endocrine and metabolic alteration than for the etiopathogenetic mechanisms. The appearance of a particular androgenic phenotype is determined by a sum of genetic and environmental factors, but mostly by body weight.

Malemedicine.medical_specialtymedicine.drug_classBiologyAndrogen ExcessDiagnosis DifferentialInsulin resistancePolycystic ovary syndrome hyperandrogenism androgen excess insulin resistance idiopathic hirsutismInternal medicinemedicineEndocrine systemHumanshirsutismHyperandrogenismObstetrics and Gynecologymedicine.diseaseAndrogenPhenotypePolycystic ovaryEndocrinologyReproductive MedicinePractice Guidelines as TopicAndrogensFemaleHyperandrogenismPolycystic Ovary SyndromeFertility and sterility
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Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes

2015

Contains fulltext : 153827.pdf (Publisher’s version ) (Open Access) Ablepharon macrostomia syndrome (AMS) and Barber-Say syndrome (BSS) are rare congenital ectodermal dysplasias characterized by similar clinical features. To establish the genetic basis of AMS and BSS, we performed extensive clinical phenotyping, whole exome and candidate gene sequencing, and functional validations. We identified a recurrent de novo mutation in TWIST2 in seven independent AMS-affected families, as well as another recurrent de novo mutation affecting the same amino acid in ten independent BSS-affected families. Moreover, a genotype-phenotype correlation was observed, because the two syndromes differed based s…

Models MolecularCandidate geneHirsutismProtein ConformationHeLa Cellmedicine.disease_causeTranscriptomeTwist transcription factorModelsGenetics(clinical)ExomeEye AbnormalitiesNon-U.S. Gov'tExomeGenetics (clinical)ZebrafishGeneticsMutationMicroscopyMacrostomiaSetleis syndromeHypertelorismResearch Support Non-U.S. Gov'tHypertrichosiEyelid DiseaseGENÉTICAPhenotypeEyelid DiseasesAbnormalitiesMultipleSequence AnalysisHumanChromatin ImmunoprecipitationMolecular Sequence DataMutation MissenseHypertrichosisAbnormalities; Multiple; Amino Acid Sequence; Animals; Base Sequence; Chromatin Immunoprecipitation; Exome; Eye Abnormalities; Eyelid Diseases; HeLa Cells; Hirsutism; Humans; Hypertelorism; Hypertrichosis; Macrostomia; Microscopy; Electron; Molecular Sequence Data; Mutation; Missense; Protein Conformation; Repressor Proteins; Sequence Analysis; DNA; Skin Abnormalities; Twist Transcription Factor; Zebrafish; Models; Molecular; Phenotype; Genetics; Genetics (clinical)Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0]BiologyResearch SupportElectronArticleFrameshift mutationGeneticAblepharon macrostomia syndromeSkin AbnormalitieGeneticsmedicineJournal ArticleAnimalsHumansAbnormalities MultipleAmino Acid SequenceNeurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]Base SequenceAnimalTwist-Related Protein 1MolecularSequence Analysis DNADNARepressor Proteinmedicine.diseaseRepressor ProteinsTwist Transcription FactorEye AbnormalitieMicroscopy ElectronMutationSkin Abnormalitiessense organsMissenseNanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]HeLa CellsAmerican journal of human genetics
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Consensus On Women'S Health Aspects Of Polycystic Ovary Syndrome (Pcos)

2012

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females with a high prevalence. The etiology of this heterogeneous condition remains obscure and its phenotype expression varies. Two, widely cited, previous ESHRE/ASRM-sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008). The present third PCOS consensus paper summarizes current knowledge and identifies knowledge gaps regarding various women's health aspects of PCOS. Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, preg…

Settore MED/09 - Medicina InternaConsensus Development Conferences as TopicmenopauseType 2 diabetesSettore MED/13 - EndocrinologiaQuality of lifecancer; cardiovascular disease; contraception; hirsutism; insulin resistance; menopause; PCOS; pregnancy; quality of life; type 2 diabetescardiovascular diseaseNeoplasmsinsulin resistancePCOShirsutismhirsutismReproductive BiologyPolycystic ovary syndrome (PCOS)RehabilitationObstetrics and GynecologyObstetrics & GynecologyMiddle AgedMenopausePhenotypecontraceptionCardiovascular DiseasesPCOS Cardiovascular risk adolescence cancer obesityFemalepregnancytype 2 diabetesPolycystic Ovary SyndromeAdultmedicine.medical_specialtyConsensusAdolescentDiabetes ComplicationsInsulin resistanceSDG 3 - Good Health and Well-beingmedicineHumanscancerMenstrual CycleAgedGynecologyPregnancybusiness.industryCancermedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaReproductive MedicineDiabetes Mellitus Type 2quality of lifeWomen's Healthbusiness
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Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society.

2012

Background Hirsutism, defined by the presence of excessive terminal hair in androgen-sensitive areas of the female body, is one of the most common disorders in women during reproductive age. Methods We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of hirsutism. Results The prevalence of hirsutism is ~10% in most populations, with the important exception of Far-East Asian women who present hirsutism less frequently. Although usually caused by relatively benign functional conditions, with the polycystic ovary syndrome leading the list of the most frequent etiologies, hirsutism may be th…

hirsutism; androgen excess; guidelinesmedicine.medical_specialtyPediatricsHirsutismMEDLINETerminal hairAndrogen ExcessSettore MED/13 - EndocrinologiaIntervention (counseling)EpidemiologyMedicineHumansguidelineshirsutismSocieties MedicalHirsutism PCOS Hyperandrogenism Adrenal hyperplasia idiopathic hirsutismGynecologybusiness.industryObstetrics and Gynecologymedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaPolycystic ovaryReproductive Medicinehirsutism androgen excess terminal hair polycystic ovary syndrome guidelinesEtiologyAndrogensFemaleandrogen excessbusinessHair FolliclePolycystic Ovary SyndromeHuman reproduction update
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